Redefining the
Origins of ALS

Vesalic is focused on addressing dysregulated systemic processes that may contribute to the development and progress of neurodegenerative diseases (NDDs) years before symptom onset.

DISCOVER Vesalic

Pushing New Boundaries to Address ALS

Most investigations for ALS and other NDDs have centered on where the damage can be observed – in the brain and central nervous system (CNS). To date, they have yielded little success. 

We are pioneers of a broader, emerging paradigm shift where mounting evidence suggests NDDs are manifestations of broader systemic biological dysfunction.

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Our Science

Understanding and Addressing Complex Systemic Biology of ALS

Our discoveries of systemic metabolic dysregulation underpin the novel investigational therapeutic we are developing to intercept a root cause of ALS and our novel biomarker-based technology for early and accurate disease detection.

Both our therapeutic candidate and our biomarker technology can be utilized in the monogenic and sporadic ALS setting.

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Experienced Team, Broad Network

Our deeply experienced team and world-class academic advisory network are enabling us to accelerate our therapeutic and diagnostic advancements for ALS and potentially other NDDs

Meet our team

Publications and Presentations

We’re excited to share our discoveries and progress with the scientific community.

July 2026

Extracellular Vesicle Lipid Alterations Define Systemic Biomarkers Of Disease Biology In ALS, Alzheimer’s, And Parkinson’s Disease

  • Alzheimer’s Association International Conference (AAIC), London, United Kingdom
June 2026

Redefining Neurodegenerative Disease: From Systemic Biology to Transformative Therapeutics

  • XX Conference of Italian Researchers in the World (Virtual), Rome, Italy
May 2026

Neurodegeneration Through the Lens of Longevity: From Systemic Biology to Transformative Therapeutics

  • Milan Longevity Summit

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